Development and in vitro evaluation of Silica-based iron oxide particles suitable for clinical application of cellular imaging with MRI
CM Langer, N Raschzok, M Mogl, S Rohn, K Nehls, C Schmidt, L Stelter, L Lüdemann, U Teichgräber, IM Sauer · Zeitschrift für Gastroenterologie · 2011 · Heft 01
Bibliografische Angaben
Zusammenfassung
Introduction: Magnetic Resonance Imaging (MRI) can be used for non-invasive monitoring after liver cell transplantation (LCT), but clinical applicable micron-sized particles are not available. Aim of this study was the development a new class of micron-sized particles for cellular imaging based on clinical applicable materials. Material and Methods: We developed silica-based particles (1.18µm) with different surface modifications: positively charged Poly-L-Lysin, neutral Streptavidin, and negative COOH-groups. Huh7-cells, primary rat hepatocytes, and primary human hepatocytes were used for in vitro evaluation. C…
