Hepatitis C virus (HCV)-specific CD8 T-cells in HCV-seronegative individuals: Frequency and T-cell receptor repertoire (TCR)
R Bakshi, B Heidrich, B Calle Serrano, SV Pothakamuri, MP Manns, H Wedemeyer, M Cornberg, V Schlaphoff · Zeitschrift für Gastroenterologie · 2011 · Heft 01
Bibliografische Angaben
Zusammenfassung
Memory CD8 T-cells cross-reactive with a heterologous virus have shown to provide either protective immunity and/or immune pathology. In humans, proliferation of cross-reactive CD8 memory T-cells has been implicated in infectious mononucleosis (IM) and subfulminant acute HCV-infection. Since each individual has its own private immune repertoire, the frequency of memory T cells polyspecific to HCV can vary and the specificity is determined by the CDR3 of the TCR. This study aimed to determine the frequency and TCR of HCV-specific CD8 T-cells in HCV-seronegative individuals with different risk profiles for HCV tra…
