Common Vitamin D Receptor (NR 1I1) gene polymorphisms and 25-OH vitamin D serum levels influence fibrosis progression and hepatic MMP-9 expression in chronic hepatitis C patients
JC Mertens, K Baur, J Schmitt, R Iwata, B Stieger, P Frei, A Al-Deb'i, B Seifert, B Müllhaupt, A Geier · Zeitschrift für Gastroenterologie · 2011 · Heft 01
Bibliografische Angaben
Zusammenfassung
Aims: The vitamin D receptor (VDR) pathway mediates antiinflammatory and antifibrotic effects in hepatic stellate cells. In chronic HCV pts, 25-OH-vitamin D levels are associated with stage of fibrosis and inflammation. We examined if VDR gene polymorphisms (SNP) and low serum vitamin D lead to altered hepatic gene expression and rapid fibrosis progression in HCV pts. Methods: 251 HCV pts received VDR genotyping (Cdx2 rs11568820, bat haplotype: Bsm rs1544410, Apa rs 7975232, Taq rs 731236). Exclusion criteria: HBV/HIV coinfection, alcohol >40g/d, morbid obesity. Hepatic mRNA expression of MMP-9 was quantified in…
