The RIST Strategy: Molecular-Based Multimodal Treatment Regimens in Pediatric Oncology

Despite the success story of childhood oncology, the outcome of several pediatric diseases like stage IV neuroblastoma (NB), glioblastoma multiforme (GBM) and relapsed/refractory solid tumors remains dismal. Over the last decade our molecular understanding of the pathophysiology of cancer led to the development of multiple new substances that specifically target pivotal pathogenetic oncological pathways. Nevertheless only a few diseases profited from this research and most established therapeutic regimens rely further on conventional chemotherapy. We developed a multimodal molecular-based therapy regimen that co…