The KidsCancerKinome – Validation of Drug Targets for High Risk Childhood Cancers
HN Caron, EM Westerhout, M Kool, JJ Molenaar, PJ Stroeken, M Den Boer, S Segers, S Clifford, O Delattre, B Geoerger, M Benetkiewicz, C Lanvers, R Warps, R Pieters, T Pietsch, M Holst, J Renshaw, M Serra, K Scotlandi, J Shipley, G Vassal, O Degrand, AC Verschu… · Klinische Pädiatrie · 2010 · Heft 12
Bibliografische Angaben
Zusammenfassung
The aim of KCK is the pre-clinical selection and validation of drug targets and corresponding targeted drugs for 6 high-risk childhood cancers. The KCK consortium focuses on six aggressive childhood tumors, killing ˜2000 children in Europe annually, i.e Ewing sarcoma, osteosarcoma, rhabdomyosarcoma, neuroblastoma, medulloblastoma and ALL. The KidsCancerKinome (KCK) project is funded by the EU in the FP6 programme and consists of 9 tumor biology labs in 4 European countries. The experimental approach encompasses: target presence analyses (mRNA and protein expression of the human kinome) molecular validation of ki…
