CareLit Fachartikel
Cell Death Pathways: Sensitivity and Resistance in Leukemia
KM Debatin · Klinische Pädiatrie · 2010 · Heft 12
Dokument
1108850
CareLit-ID
Jahr
2010
Publikation
PDF
nein
Metadaten
DOI
ja
zitierfähig
Bibliografische Angaben
Zusammenfassung
Research on cell death programs has now entered a phase of translation into clinical application. Cancer is a complex disease. Research in our own laboratory has aimed to identify mechanisms of apoptosis resistance in tumor cells and identified e.g. proteins of the IAP-family as key modulators and inhibitors of cell death induction by death receptor agents such as TRAIL and cytotoxic drugs. Translation of apoptosis research into clinical application has to deal with the complexity and heterogeneity of clinical tumor. In a NOD/SCID mouse model for pediatric acute lymphoblastic leukemia we have addressed issues of…
Schlagworte
Apoptosis
Tumor
Cytochrome C
Cytochrome
Diagnosis
Klinische Pädiatrie
