CareLit Fachartikel
Arabinogalactan protects mice from allergic asthma via modulation of dendritic cell function
M Peters, M Kauth, E von Mutius, O Holst, A Bufe · Pneumologie · 2011 · Heft 02
Dokument
1108852
CareLit-ID
Jahr
2011
Publikation
PDF
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Metadaten
DOI
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Zusammenfassung
We have previously shown that dust from cowsheds of traditional alpine farms contains substances that protect from experimental allergic lung disease in a mouse model of asthma. Now we present evidence that plant arabinogalactans (AG) are contained in cowshed dust extract (CDE) in high concentration and after isolation show protective activity in vivo. Mice treated with these polysaccharides during sensitization showed dramatically reduced airway eosinophila, IgE production and release of Th2 cytokines. Furthermore, we were able to show that AG as found in cowshed dust is derived from feeding material consisting…
Schlagworte
Dendritic Cells
Asthma
Cytokines
Farms
Alopecurus
After
Pneumologie
