CareLit Fachartikel

Effects of multi-kinase inhibitors on pulmonary vascular and right ventricular remodelling

B Kojonazarov, A Sydykov, H Luitel, D Kosanovic, S Pullamsetti, X Tian, S Evans, P Phillips, N Davie, N Weissmann, F Grimminger, W Seeger, HA Ghofrani, RT Schermuly · Pneumologie · 2011 · Heft 03

Dokument
1108955
CareLit-ID
Jahr
2011
Publikation
PDF
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Metadaten
DOI
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Bibliografische Angaben

Zeitschrift
Pneumologie
Autor:innen
B Kojonazarov, A Sydykov, H Luitel, D Kosanovic, S Pullamsetti, X Tian, S Evans, P Phillips, N Davie, N Weissmann, F Grimminger, W Seeger, HA Ghofrani, RT Schermuly
Ausgabe
Heft 03 / 2011
Seiten
–
Erschienen: 2011-03-10 00:00:00
ISSN
0934-8387
DOI
10.1055/s-0031-1272117

Zusammenfassung

Background: Inhibition of receptor tyrosine kinases has been shown to improve experimental pulmonary hypertension (PH) and PAH in patients. However, little is known about the effects of current PAH therapies including receptor tyrosine kinase inhibitors on heart remodeling. Aim of this study was to investigate the effects of the multikinase inhibitors sunitinib and sorafenib on right ventricular (RV) remodeling. Methods: We compared the effects of two multi-kinase inhibitors on RV remodeling in rats subjected either to monocrotaline (MCT)-induced PH or pulmonary artery banding (PAB). MCT and PAB rats were treate…

Schlagworte

Pulmonary Artery After Pneumologie