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Driving murine embryonic stem cells toward endothelial phenotype for cell-based therapy

M Raissi, S Becker, H Sauer, S Liebner, W Seeger, R Voswinckel · Pneumologie · 2011 · Heft 03

Dokument
1108975
CareLit-ID
Jahr
2011
Publikation
PDF
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Metadaten
DOI
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Bibliografische Angaben

Zeitschrift
Pneumologie
Autor:innen
M Raissi, S Becker, H Sauer, S Liebner, W Seeger, R Voswinckel
Ausgabe
Heft 03 / 2011
Seiten
–
Erschienen: 2011-03-10 00:00:00
ISSN
0934-8387
DOI
10.1055/s-0031-1272327

Zusammenfassung

Endothelial cells (ECs) play a central role in many pathological conditions related to cardiovascular diseases, including coronary artery disease, smoking, and pulmonary hypertension. One of the therapeutic modalities for diseases with underlying endothelial dysfunction is cell-based therapy. In this study, we took advantage of embryonic stem cells (ESCs), owing to their unlimited self-renewal capacity and potential to develop into functional cell types for further use in animal disease models. To achieve pure ECs, we made two lentiviral-based constructs, wherein the antibiotic resistance and reporter genes were…

Schlagworte

Cells Endothelial Diseases Disease Pulmonary Hypertension Therapeutic Their Further Animal Models Antibiotic Pneumologie