Multi-modal molecular imaging of anti-angiogenic treatment strategies of experimental gliomas
T. Viel, P. Boehm-Sturm, P. Monfared, S. Schäfers, G. Schneider, B. Neumaier, F. Thorsen, M. Hoehn, R. Bjerkvig, H. Miletic, A.H. Jacobs · Klinische Neurophysiologie · 2011 · Heft 03
Bibliografische Angaben
Zusammenfassung
Background: Glioblastomas are highly vascularized tumors. Hence, anti-angiogenic treatments are an attractive option. However, they are limited by the potential evolution of the tumor cells towards infiltrative, angiogenic independent cells, leading to recurrence of the cancer. Development of imaging methods to non-invasively characterize the tumor vasculature in terms of vessel size, density and neo-angiogenesis and the tumor proliferation is essential to assess the effect of anti-angiogenic treatment. Aim: The goal of our study was to describe changes in tumor vasculature and proliferation upon Bevacizumab tre…
