Gait and posture in pre-manifest and symptomatic huntington's disease
H. Beckmann, S. Rumpf, N. Bechtel, H.W. Lange, C. Saft, R. Hoffmann, P. Kraus, K. Barth, S. Trautmann, B. Landwehrmeyer, R. Reilmann · Klinische Neurophysiologie · 2011 · Heft 03
Bibliografische Angaben
Zusammenfassung
Background: HD patients develop impairment of balance & gait, frequently resulting in injuries. Quantitative assessment of gait and balance may serve as surrogate marker for motor dysfunction. Object: Can GAITRite(GR) & Force Plate(FP)detect motor deficits in premanifest HD (pHD, do deficits correlate to severity of phenotype as assessed by UHDRS-TMS, TFC and FA? Subject: Symptomatic HD (sHD) patients (n=40), pHD (n=26) & controls (n=30) were (1) placed on FP with eyes open & closed for 25s. Subjects were instructed to stand still. Stability of center of mass (COM) location was assessed by variables SURFACE, VEL…
