CareLit Fachartikel
4-HPR (fenretinide) sensitizes human neuroblastoma cells for ch14.18-mediated NK cell and complement killing
A Shibina, D Seidel, S Somanchi, DA Lee, HN Lode, CP Reynolds, N Huebener · Klinische Pädiatrie · 2011 · Heft 05
Dokument
1109172
CareLit-ID
Jahr
2011
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Zusammenfassung
Introduction: 4-HPR is a synthetic retinoid that induces apoptosis in cancer cells mainly through the accumulation of ceramides. We tested the hypothesis whether 4-HPR and ch14.18 would work additively in NK cell-mediated killing when applied in combination. Methods: 6 GD2+, drug-resistant human NB cell lines were treated with 4-HPR and analyzed for GD2 expression by flow cytometry (FC) and in ADCC and CDC assays mediated by anti-GD2 antibody ch14.18. Further, we induced s.c. tumors in NOD/SCID mice and treated them with 4-HPR by oral gavage for 12 days. Then, tumor cells were isolated and GD2 expression levels…
Schlagworte
ADCC
Tumor
Apoptosis
Ceramides
Work
After
Klinische Pädiatrie
