Apolipoprotein A5 (apoA5), besides accelerating plasma triglyceride hydrolysis, mediates triglyceride reduction via an LDL receptor related protein 1 (LRP1) dependent pathway

Aims: Apolipoprotein A5 (apoA5) is regulates plasma triglyceride (TG) levels. Genetic aberrations (SNP's) in its gene lead to increased plasma TG in humans; apoA5 deficiency by structural mutations yields into severe hypertriglyceridemia type I or V. ApoA5 reduces plasma TG levels by activating or stabilizing endothelial lipoprotein lipase (LPL). However, due to its binding properties and its high intra-hepatocellular concentration it had been postulated, that apoA5 may also mediate hepatic lipoprotein uptake. A possible involvement of LDL receptor related protein 1 (LRP1) during this process is the focus of the…