Sex differences in cardiac hypertrophy are linked to adipose tissue lipolysis
A Foryst-Ludwig, M Kreissl, C Sprang, B Thalke, C Böhm, V Benz, J Spranger, V Regitz-Zagrosek, T Unger, U Kintscher · Diabetologie und Stoffwechsel · 2011 · Heft 05
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Zusammenfassung
Adipose tissue (AT) undergoes profound molecular changes during exercise. Women exhibit enhanced exercise-mediated AT-lipolysis when compared to men. Exercise-induced cardiac hypertrophy has been recently identified to be regulated in a sex-specific manner. The aim of the project was to investigate the influence of sex-specific differences in AT-lipolytic activity on exercise-induced cardiac hypertrophy. Female and male C57BL/6J mice were challenged with active treadmill running for 1.5h/day (0.25m/s) over 4 weeks. Mice underwent cardiac and metabolic phenotyping including echocardiography, small-animal PET, and…
