CareLit Fachartikel
Non-oxydative ethanol metabolites decrease intracellular ATP level in human pancreatic ductal epithelial cell line
J Maléth, Z Rakonczay, V Venglovecz, P Hegyi · Zeitschrift für Gastroenterologie · 2011 · Heft 05
Dokument
1109267
CareLit-ID
Jahr
2011
Publikation
PDF
nein
Metadaten
DOI
ja
zitierfähig
Bibliografische Angaben
Zusammenfassung
Background: Excessive ethanol consumption is one of the most common causes of acute pancreatitis. Several studies suggest that the toxic effects of alcohol are mediated by its non-oxidative metabolites. Criddle et al. found that fatty acid ethyl esters (FAEE) induce reversible, dose-dependent calcium signalling and inhibit ATP production in isolated pancreatic acinar cells. However, no information is available concerning the effects of ethanol metabolites on pancreatic ductal epithelial cells (PDEC). The aim of this study was to characterize the effects of palmitoleic acid ethyl ester (POAEE) and palmitoleic aci…
Schlagworte
Adenocarcinoma
Acinar Cells
Bicarbonate
Calcium
Work
Zeitschrift für Gastroenterologie
