Mechanisms associated with insulin resistance in adenosine A1 receptor deficient mice
R Faulhaber-Walter, D Mizel, L Li, S Kim, J Zhang, M Chen, Y Huang, LM Chen, J Briggs, O Gavrilova, J Schnermann · Diabetologie und Stoffwechsel · 2011 · Heft 08
Bibliografische Angaben
Zusammenfassung
Fragestellung: In previous studies using glucose tolerance tests, euglycemic-hyperinsulinemic clamp studies, insulin-releasing tests and body composition analyses we have demonstrated that adenosine-A1-receptor-deficient mice (A1AR-/-) are glucose-intolerant and insulin-resistant (Faulhaber-Walter et. al., DDG 2008). The present experiments were performed to investigate possible underlying mechanisms. Methodik: Wild type (Wt) and A1AR-/- mice of C57Bl/6 and Swiss background were investigated. Food/water intake and body weight changes were measured for 10 days during individual cage housing. Spontaneous locomotor…
