CareLit Fachartikel
Activation of constitutively active NFATc1 in murine pancreas triggers cellular apoptosis: a powerful and effective innate restraint to NFAT-induced tumorigenesis
SK Singh, S Kernig, D Yazici, K Reutlinger, TM Gress, V Ellenrieder · Zeitschrift für Gastroenterologie · 2011 · Heft 08
Dokument
1109615
CareLit-ID
Jahr
2011
Publikation
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Zusammenfassung
Introduction: The nuclear factor of activated T cells (NFAT) family of transcription factors has recently been implicated with a role in tumorigenesis. Forced expression of a constitutively active NFATc1 mutant (c.a.NFATc1) has been shown to transform immortalized murine fibroblasts in vitro, while constitutive activation of the NFAT-signaling pathway has been found in a number of human cancers, where it has been shown to contribute towards various aspects of the tumor phenotype. Aims: To explore the direct consequences of c.a.NFATc1 in pancreatic ductal adenocarcinoma (PDAC). Methods: We introduced endogenous e…
Schlagworte
Apoptosis
Tumor
Chromatin Immunoprecipitation
Adenocarcinoma
Chromatin
Zeitschrift für Gastroenterologie
