Inhibitory effect of hepatocarcinogenesis by increased glucosylceramide in Gba2 knockout mice
S Boussettaoui, MA Gonzalez-Carmona, A Vogt, F Lammert, T Sauerbruch, Y Yildiz · Zeitschrift für Gastroenterologie · 2011 · Heft 08
Bibliografische Angaben
Zusammenfassung
Background and aims: Glycosphingolipids are members of membrane lipids and distributed widely in eukaryotic cells and play roles in the regulation of immunity, inflammation, angiogenesis and tumor growth. Different studies have shown that administration of ß-glucosylceramide in vivo and in vitro suppressed tumor growth. The Gba2 knockout mice accumulate clearly the naturally occurring glucosylceramide in various tissues, including the liver. Our aim was to investigate the role of hepatic increased glucosylceramide in the diethylnitrosamine-induced hepatocarcinogenesis model. Methods: Groups of eight 9–10 month o…
