Common FOXO1 variant, a risk factor for impaired glucose tolerance and diabetes, in gallstone patients: Analysis of three independent cohorts
M Krawczyk, R Schirin-Sokhan, M Mahler, H Molina, L Azocar, M Acalovschi, JF Miquel, F Lammert · Zeitschrift für Gastroenterologie · 2011 · Heft 08
Bibliografische Angaben
Zusammenfassung
Background: Gallstones (GS) develop frequently in individuals with metabolic syndrome. Of note, forkhead transcription factor (FOXO1) regulates the hepatobiliary cholesterol secretion leading to GS [1], and the FOXO1 variant (rs2721068) increases the diabetes risk [2]. Here, we combine case-control and sib-pairs analyses and investigate the FOXO1 polymorphism in gallstone patients. Methods: We analyzed three independent cohorts from German (184 patients with GS and 184 controls), Romania (234 sibs with GS from 107 families and 260 controls), and Chile (485 patients and 229 controls). The FOXO1 polymorphism rs272…
