CXCL9 attenuates CCl4 induced angiogenesis and liver fibrosis in vivo
H Sahin, C Grouls, MM Zaldivar, P Schmitz, E Borkham-Kamphorst, MJ Moeller, F Kiessling, C Trautwein, HE Wasmuth · Zeitschrift für Gastroenterologie · 2011 · Heft 08
Bibliografische Angaben
Zusammenfassung
Background and aims: Previous findings indicate that the chemokine receptor CXCR3 and its ligands are crucially involved in liver fibrosis. Neoangiogenesis critically contributes to liver scarring but the specific role of ELR-negative, angiostatic chemokines in the disease process remains unclear. Here we investigate the role of neoangiogenesis in CCl4 induced liver fibrosis in Cxcr3-/- and wild-type mice. Furthermore, we assess the possibiliy of attenuation of angiogenesis and associated liver damage by therapeutic treatment with the angiostatic chemokine Cxcl9. Methods: Liver fibrosis was induced by intraperit…
