CareLit Fachartikel
Tracking genetic variation underlying differenzial reaction to TGF-beta signalling in inbred mouse strains
R Müllenbach, I Ilkavets, S Dooley, F Lammert · Zeitschrift für Gastroenterologie · 2011 · Heft 08
Dokument
1109634
CareLit-ID
Jahr
2011
Publikation
PDF
nein
Metadaten
DOI
ja
zitierfähig
Bibliografische Angaben
Zusammenfassung
Background: TGF-β is the central pro-fibrogenic cytokine in the liver. In hepatocytes, cell death by apoptosis, growth arrest by cellular senescence or contribution towards healing by epithelial-mesenchymal transition are possible outcomes. We speculate that genetic differences underlying differences in response to TGF-β signalling may be involved in predisposition to fibrosis or hepatocellular carcinoma. Aims: Our aim is to identify differences in the transcriptional response of hepatocytes from genetically distinct inbred mouse strains to TGF-β signalling. Methods: We characterised the transcriptional response…
Schlagworte
Activating Transcription Factor 3
Apolipoprotein A-V
ADP-Ribosylation
Chemokine
C-
Apoptosis
Claudin-4
Cytokine
Apolipoprotein(a)
After
Zeitschrift für Gastroenterologie
