Identification of a CpG Island Methylator Phenotype (PA-CIMP) in a Subgroup of Pilocytic Astrocytoma
H Witt, DTW Jones, M Zapatka, H Cin, M Ryzhova, M Remke, AE Kulozik, O Witt, P Lichter, A Korshunov, SM Pfister · Klinische Pädiatrie · 2011 · Heft 11
Bibliografische Angaben
Zusammenfassung
The most common pediatric brain tumors are pilocytic astrocytomas (PA), classified as WHO°I. These tumors arise most often within cerebellum, and here complete resection is typically possible, leading to a favorable prognosis. By contrast, tumors in other locations, however, e.g. diencephalic, brain stem, or optic tract tumors, where complete resection is often challenging are associated with much worse prognosis. PA are discussed to be a “single pathway disease” because MAPK pathway activation (e.g. by KIAA1549:BRAF fusion, BRAF V600E mutation, etc.) has been demonstrated in approximately 80% of cases. So far n…
