Expression of GLUT-1 in human eutopic endometrium, in peritoneal endometriotic lesions, and in deep-infiltrating endometriosis

Introduction: Glucose metabolism plays a important role in human tissues. In this respect, GLUT-1 seems to be one of the major factors in the complex hypoxia orchestra. Recent studies implicated that estrogen (E2) and progesterone (P) might play an important role in the regulation of glucose metabolism by regulation the glucose transporter (GLUT) expression. There is some evidence that defective glucose metabolism leads to infertility. Methods: 35 women with deep-infiltrating endometriosis who underwent rectum resection where included in the study. Immunohistochemistry (IHC) combined with a modified Remmele-Steg…