CareLit Fachartikel

Genetic Low Nephron Number Hypertension is Associated with Altered Expression of Osteopontin and One of Its Receptors, CD44, but not Alpha(v)-Integrin during Nephrogenesis

AL Freese, M Wehland, F Freese, A Schulz, R Kreutz, L Rothermund · Zeitschrift für Geburtshilfe und Neonatologie · 2011 · Heft 11

Dokument
1109769
CareLit-ID
Jahr
2011
Publikation
PDF
nein
Metadaten
DOI
ja
zitierfähig

Bibliografische Angaben

Zeitschrift
Zeitschrift für Geburtshilfe und Neonatologie
Autor:innen
AL Freese, M Wehland, F Freese, A Schulz, R Kreutz, L Rothermund
Ausgabe
Heft 11 / 2011
Seiten
–
Erschienen: 2011-11-17 00:00:00
ISSN
0948-2393
DOI
10.1055/s-0031-1293277

Zusammenfassung

Ziel: Low nephron number may represent a major determinant of human primary hypertension in adult life. This hypothesis is supported by a genetic rat model, the Munich-Wistar Frömter (MWF) rat, which demonstrates an inherited deficit in nephron number and the development of spontaneous hypertension. Osteopontin and its receptors cd44 and alpha(v)beta(3)integrin play a role in growth and differentiation processes during nephrogenesis. We demonstrate that the low nephron number present during fetal development is associated with altered expression of osteopontin and one of its receptors, cd44, but not alpha(v)-int…

Schlagworte

Integrin alpha(v). Osteopontin cd44 fetal programming hypertension kidney development low nephron number Nephron Number Renal Expression During Development Fetal Mrna-Expression Genetic