Downregulation of methylthioadenosine phosphorylase (MTAP) expression in chronic liver disease promotes hepatic inflammation and fibrosis
B Czech, D Valletta, M Saugspier, K Dettmer, A Stevens, C Dorn, TS Weiss, A Bosserhoff, P Oefner, C Hellerbrand · Zeitschrift für Gastroenterologie · 2012 · Heft 01
Bibliografische Angaben
Zusammenfassung
Methylthioadenosine phosphorylase (MTAP) the rate-limiting enzyme in the methionine and adenine salvage pathway catalyzes the phosphorylation of 5´-deoxy–5´-(methylthio)adenosine (MTA) which is a by-product of polyamine synthesis. The aim of this study was to assess MTAP expression and function during the progression of chronic liver disease. Methods and Results: MTAP mRNA and protein were reduced in the murine bile-duct ligation model and in patients with chronic liver disease, which was accompanied by increased hepatic and serum levels of MTA as assessed by liquid chromatography tandem mass spectrometry. In vi…
