CareLit Fachartikel
The chemokine receptor CCR8 critically controls hepatic macrophage migration and differentiation in murine liver fibrosis
F Heymann, L Hammerich, N Gassler, T Luedde, C Trautwein, F Tacke · Zeitschrift für Gastroenterologie · 2012 · Heft 01
Dokument
1109818
CareLit-ID
Jahr
2012
Publikation
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Metadaten
DOI
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Zusammenfassung
Aims: Chemokines are important regulators of immune cell infiltration upon liver injury, thereby controlling hepatic inflammation and fibrosis. The chemokine receptor CCR8 can affect trafficking of monocytes/macrophages, monocyte-derived dendritic cells (DCs) and T helper cell subsets, but its role in liver diseases is currently unknown. Methods: ccr8-/- and wildtype (wt) mice were subjected to chronic experimental hepatic injury models (carbon tetrachloride (CCl4), surgical bile duct ligation). Results: Ccr8-/- mice displayed attenuated liver damage (ALT, histology, TUNEL) compared to wt mice, and were also pro…
Schlagworte
Chemokine
Leberfibrose
Makrophagen
Mausmodelle
Monozyten
Dendritic Cells
Chemokines
Affect
Zeitschrift für Gastroenterologie
