CareLit Fachartikel

Dll4 plays a critical role in HBV-associated liver fibrogenesis

Y Liu, C Meyer, I Ilkavets, Q Li, A Müller, S Dooley, HL Weng · Zeitschrift für Gastroenterologie · 2012 · Heft 01

Dokument
1109819
CareLit-ID
Jahr
2012
Publikation
PDF
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Metadaten
DOI
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Bibliografische Angaben

Zeitschrift
Zeitschrift für Gastroenterologie
Autor:innen
Y Liu, C Meyer, I Ilkavets, Q Li, A Müller, S Dooley, HL Weng
Ausgabe
Heft 01 / 2012
Seiten
–
Erschienen: 2012-01-09 00:00:00
ISSN
0044-2771
DOI
10.1055/s-0031-1295757

Zusammenfassung

Background & Aims: Notch signaling is crucial in the development of metazoans, determining cell fate, and is directly linked to multiple human organ disorders. In human, 5 Notch ligands (Jagged–1, Jagged–2, Delta–1, Delta–3 and Delta–4) and 4 receptors (Notch–1, Notch–2, Notch–3 and Notch–4) have been identified. Mutation of Jagged–1 gene leads to Alagille syndrome. However, patients with Alagille syndrome usually do not progress into serious liver fibrosis. In the present study, we investigated the role of Notch ligands in HBV associated liver fibrogenesis. Methods: The expression of Notch ligands, including Ja…

Schlagworte

fibrosis HSC Alagille Syndrome Connective Tissue Growth Factor Connective Tissue Actin Zeitschrift für Gastroenterologie