CareLit Fachartikel
Bile acids downregulate the human hepatic organic anion transporter 7
C Jüngst, K Klein, J Eloranta, G Kullak-Ublick · Zeitschrift für Gastroenterologie · 2012 · Heft 01
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1109823
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2012
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Zusammenfassung
Organic anion transporters (OATs) play a major role for the uptake, distribution and elimination of a wide range of exogenous and endogenous compounds. The human organic anion transporter 7 (hOAT7, SLC22A9) has been characterized as the first liver-specific member of the OAT family and mediates exchange of sulfate-conjugates for small chain fatty acids across the sinusoidal membrane. Nuclear receptors and their ligands, such as bile acids, are key regulators of hepatic membrane transporters at the transcriptional level. Bile acids have been shown to decrease gene transcription via repression of the transcription…
Schlagworte
organic anion transporter 7 (SCL22A9)
transcriptional regulation
hepatocyte nuclear factor-1a
small heterodimer partner
bile acids
cholestasis
Chenodeoxycholic Acid
Lead
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Zeitschrift für Gastroenterologie
