CareLit Fachartikel
Protection against Cholestasis and Ischemia in vitro by Ursodeoxycholyl Lysophosphatidylethanolamide (UDCA-LPE) is Associated with Upregulation of Anti-apoptotic Proteins
M Sellinger, D Gotthardt, W Stremmel, W Chamulitrat · Zeitschrift für Gastroenterologie · 2012 · Heft 01
Dokument
1109830
CareLit-ID
Jahr
2012
Publikation
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Metadaten
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Zusammenfassung
Introduction: An increase of toxic bile acids such as glycochenodeoxycholic acid (GCDCA) frequently occurs in an early phase of liver transplantation. Ischemia during transplantation can cause hepatic cholestasis and damage of intrahepatic biliary epithelial cells. Both stresses contribute to the failure in liver transplantation. We aim to test the effectiveness of UDCA-LPE in inhibition of apoptosis induced by GCDCA and ischemia. Methods: Mouse hepatocytes were isolated and treated with 50µM GCDCA for 15h. As an experimental model of ischemia, CoCl2 at 500–750µM was used to treat the intrahepatic biliary epithe…
Schlagworte
Mcl-1 stabilization
apoptosis
cytoprotective agent
ischemia
liver transplantation
Transplantation
Caspase 3
Cholestasis
Work
Zeitschrift für Gastroenterologie
