CareLit Fachartikel
Hepatic fibrosis attenuates virus-specific CD8 T cell immunity causing virus persistence
Z Abdullah, K Riethausen, S Geiger, E Muralev, J Tribica, P Knolle · Zeitschrift für Gastroenterologie · 2012 · Heft 01
Dokument
1109831
CareLit-ID
Jahr
2012
Publikation
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Metadaten
DOI
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Zusammenfassung
The impact of liver fibrosis or cirrhosis on hepatic immunity against infectious microorganisms is unknown. Patients suffering from liver fibrosis or cirrhosis are more susceptible to viral and bacterial infections, which often persist in these patients. Yet, the underlying cellular and molecular mechanisms have not been elucidated. Using a novel murine model system, we demonstrated that liver cirrhosis and fibrosis induced by CCL4 or bile-duct ligation rendered mice unable to clear infection with the Lymphocytic choriomeningitis virus LCMV (WE strain). These mice show impaired effector functions of virus-specif…
Schlagworte
Hepatic fibrosis
LCMV
viral infection
Bacterial Infections
After
Zeitschrift für Gastroenterologie
