Panobinostat treatment determines oncogenic miRNAs down-regulation in liver cancer cells

Background. miRNAs represent new targets for future cancer therapy due to their tumorigenic and tumorsuppressor activities. In particular, miR–19a, miR–19b–1 and miR–30a promote tumor progression by blocking the translation of proteins related to apoptotic and autophagic cell death like APAF1 and Beclin1 in many solid tumors. We have previously shown that panobinostat, a potent pandeacetylase inhibitor, was able to promote the modulation of hsa-let7b and its related target HMGA2 favouring the block of cellular proliferation in liver cancer cells (HCC). Here we clarify, for the first time, that panobinostat is re…