CareLit Fachartikel
Expression of prospero-related homeobox 1 (prox–1) transcription factor and epithelial adhesion molecule (EpCAM) in a rat model of intrahepatic cholangiocarcinogenesis
N Naz, IA Mailk, F Schultz, T Mansuroglu, G Ramadori · Zeitschrift für Gastroenterologie · 2012 · Heft 01
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1109842
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Jahr
2012
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Zusammenfassung
Deregulation of homeobox genes may give rise to tumorigenesis in target organs (1). Immuhistochemical studies have shown that the Prospero-related homeobox 1 (Prox–1) gene is expressed in mature hepatocytes but is not detectable in non-parenchymal liver cells (2). EpCAM is a surface marker on human hepatic stem/progenitor cells that is reported as absent on mature hepatocytes.However, hepatocytes (that have recently derived from hepatobiliary progenitors) are reported to have EPCAM surface expression in different cirrhotic livers (3). In the current study we investigated the expression pattern of Prox–1 in a rat…
Schlagworte
Bile duct cancer
Cholangiocarcinoma
EPCAM
Prox-1
Thioacetamide
After
Tumor
Zeitschrift für Gastroenterologie
