CareLit Fachartikel
Targeting the cytoskeleton inhibits proliferation of hepatoma cells by suppressing mitogenic signalling
J Schrader, TT Gordon-Walker, M Fahl, AW Lohse, JP Iredale · Zeitschrift für Gastroenterologie · 2012 · Heft 01
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1109843
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Jahr
2012
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Zusammenfassung
Hepatocellular carcinoma (HCC) develops almost exclusively on a background of chronic liver inflammation and cirrhosis. We have shown before, that hepatoma cells are able to sense and respond to the increased stiffness of the cirrhotic liver leading to increased cellular tension, stress fibre formation and proliferation. The FAK-Rho/ROCK-MLC2/Myosin pathway has been identified in other tissues to be a central regulator of cellular responses to increased environmental stiffness.The aim of the study was to evaluate the relevance of the stiffness-sensing pathway in the regulation of the cytoskeleton and to test, wh…
Schlagworte
FAK
HCC
ROCK
STAT3
Cisplatin
After
Apoptosis
Zeitschrift für Gastroenterologie
