microRNA regulation of WISP1 in pulmonary fibrosis: an in silico approach

Idiopathic pulmonary fibrosis (IPF) is the most common and devastating disorder of the lung interstitium. It is characterized by repetitive injury of the alveolar epithelium, fibroblast activation, and increased extracellular matrix production. MicroRNAs (miRNAs) are short single stranded nucleotides regulating protein expression. Differenzial expression of miRNAs has been described to act on pro-fibrotic target genes in lung fibrosis. Recently, we identified WNT1-inducible signaling pathway protein 1 (WISP1) as a novel alveolar epithelial cell-derived mediator in IPF. Here, we aim to investigate whether WISP1 e…