CareLit Fachartikel
Barrier function of the tight junction protein tricellulin
Marcel P. Conrad, Michael Fromm, Jörg-Dieter Schulzke, Susanne M. Krug · Zeitschrift für Gastroenterologie · 2012 · Heft 01
Dokument
1109985
CareLit-ID
Jahr
2012
Publikation
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Metadaten
DOI
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zitierfähig
Bibliografische Angaben
Zusammenfassung
Abstract Tricellulin is a tight junction protein localized in tricellular junctions (tTJ), the meeting points of three cells, but also in bicellular junctions (bTJ). The barrier function of tricellulin in bTJ and tTJ has been characterized by overexpression experiments in kidney tubule MDCK II cells. When expressed in the tTJ alone, tricellulin impeded the permability for macromolecules, while after expression in both, tTJ and bTJ, tricellulin impeded the permeability for macromolecules and also for ions. The surprising finding that in tTJ no changes in ion permeability occured is explained by the fact that tTJ…
Schlagworte
Claudin-2
Claudins
Lead
Observation
Anions
After
Amino Acids
Apoptosis
Claudin-5
Cytokines
Cytokine
Zeitschrift für Gastroenterologie
