Auf der Suche nach den Urprüngen epileptischer Entladungen: fMRT/EEG bei kindlichen Epilepsiesyndromen

Simultaneous recording of EEG and blood-oxygenation level-dependent (BOLD) functional MRI (EEG-fMRI) is a new non-invasive technique that allows evaluation of haemodynamic changes in the brain correlated with interictal epileptiform discharges (IED). In idiopathic generalized epilepsies, EEG-fMRI has revealed a typical network with a significant activation in the thalamus and deactivation in brain areas of the default mode network (DMN) such as precuneus, medial prefrontal cortex and parieto-temporal junction. In epileptic encephalopathies, syndrome-specific networks have been specified: bilateral activation in…