Long-range temporal correlations in the subthalamic nucleus of patients with Parkinson's Disease

Neuronal activity in the subthalamic nucleus (STN) of untreated patients with Parkinson’s disease (PD) is characterized by excessive neuronal synchronization, particularly in the beta frequency range. However, less is known about the temporal dynamics of neuronal oscillations in PD. In this respect long-range temporal correlations (LRTC) are of special interest since they quantify neuronal dynamics on different time scales and were shown to be relevant for optimal information processing in the brain. While the presence of LRTC was demonstrated in cortical data, their existence in deep brain structures remains an…