Neural activity and connectivity as predictors of the individual response to theta-burst stimulation over the motor cortex

Repetitive transcranial magnetic stimulation (rTMS) may alter cortical excitability beyond the stimulation period. However, response to rTMS may vary considerably between subjects. Here, we explored if brain activity and connectivity before stimulation can predict efficacy of excitatory intermittent theta-burst (iTBS) rTMS in healthy subjects. Methods: Nine right-handed volunteers participated in a within subject design on three different days. iTBS over the left M1 or sham stimulation over parieto-occipital cortex were applied. Effects were evaluated by means of motor evoked potentials (MEPs) using single-pulse…