CareLit Fachartikel
Reduced network switching in aging correlates with atrophy of the cholinergic basal forebrain
M Grothe, H Heinsen, S Teipel · Klinische Neurophysiologie · 2012 · Heft 03
Dokument
1110005
CareLit-ID
Jahr
2012
Publikation
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Zusammenfassung
Elderly subjects demonstrate a dysfunctional attenuation of task-induced deactivation of the default mode network (DMN) in cognitively demanding tasks1. Based on findings from animal studies, it has been suggested that the basal forebrain cholinergic system (BFCS) may play a critical role in mediating the switch from DMN activity to task-associated activity in attention-demanding situations2. We hypothesized that the reduced capability of older adults to disengage from DMN activity in cognitively demanding tasks would also be reflected in a reduced anticorrelated behavior of the spontaneous fMRI signal fluctuati…
Schlagworte
Atrophy
Basal Forebrain
Attention
Aging
Character
Klinische Neurophysiologie
