CareLit Fachartikel

Role of three childhood acute lymphoblastic leukemia-associated SNPs in a pediatric non-Hodgkin lymphoma cohort

T Bartram, K Seidemann, B Burkhardt, W Wössmann, M Zimmermann, E Ellinghaus, A Franke, S Schreiber, M Schrappe, A Reiter, M Stanulla · Klinische Pädiatrie · 2012 · Heft 04

Dokument
1110248
CareLit-ID
Jahr
2012
Publikation
PDF
nein
Metadaten
DOI
ja
zitierfähig

Bibliografische Angaben

Zeitschrift
Klinische Pädiatrie
Autor:innen
T Bartram, K Seidemann, B Burkhardt, W Wössmann, M Zimmermann, E Ellinghaus, A Franke, S Schreiber, M Schrappe, A Reiter, M Stanulla
Ausgabe
Heft 04 / 2012
Seiten
–
Erschienen: 2012-04-27 00:00:00
ISSN
0300-8630
DOI
10.1055/s-0032-1310487

Zusammenfassung

Aim: Investigation of candidate SNPs previously described to influence the risk of developing childhood acute lymphoblastic leukemia, in pediatric non-Hodgkin lymphoma (NHL). Methods: Genotyping of SNPs rs4132601 (IKZF1), rs7089424 (ARID5B) and rs2239633 (CEBPE) in 498 German pediatric NHL cases treated on protocol NHL-BFM 95 and 1832 healthy individuals from the PopGen biobank. Results: No evidence of significant differences regarding the genotype distribution of the three SNPs was found between the entire NHL population as well as specific subgroups and healthy controls. Conclusion: The analyzed SNPs in IKZF1,…

Schlagworte

Population Klinische Pädiatrie