Automated detection of epithelial changes in colorectal carcinoma

Introduction: Colorectal cancer (CRC) accosiated epithelium are characterized by characteristic pathological alterations including altered crypt arhitecture, changes of nucleus shape, size and localization. The separation of CRC samples from normal samples could be facilitated by the automatic detection of these morphometrical aberrations. Aims: Our aim was to separate routinely processed normal and CRC samples using whole slide scanning technology and advanced image analysis. The image segmentation algorithm has to detect and classify tissue elements based on their histological features, like stain intensity an…