Expression of embryonic stem cell factor Sox2 in serous ovarian carcinomas

The transcription factor SOX2 is involved in the maintenance of embryonic stem cell pluripotency and is expressed in several carcinoma types, predominantly of squamous cell origin. The gene SOX2 is located at chromosome 3q26, a region that is frequently amplified in ovarian high-grade serous carcinoma. In this study, we correlate SOX2 protein expression and gene amplification status in ovarian carcinomas with histopathological criteria and disease outcome. 215 cases of ovarian carcinomas (154 serous, 39 endometrioid, 11 clear cell, 5 mucinous and 6 transitional cell carcinomas) were analyzed by immunohistochemis…