CareLit Fachartikel
Early fat distribution as a predictor of type 2 diabetes in NZO mice
M Lubura, S Scherneck, A Zucker, A Schürmann · Diabetologie und Stoffwechsel · 2012 · Heft 05
Dokument
1110451
CareLit-ID
Jahr
2012
Publikation
PDF
nein
Metadaten
DOI
ja
zitierfähig
Bibliografische Angaben
Zusammenfassung
Aims: Excessive fat accumulation in visceral but not subcutaneous fat depots as well as ectopic fat storage in liver, skeletal muscle and pancreas are associated with an increased risk for the development of type 2 diabetes in humans. In this study we aimed to examine the influence of early fat distribution on onset of type 2 diabetes in mice. Methods: The NZO mouse is a well established model of obesity and insulin resistance. Only males develop diabetes with beta-cell failure. We fed male and female NZO mice with high-fat (60 energy percent of fat, HFD) or standard diet (9 energy percent of fat, SD) measured b…
Schlagworte
Blood Glucose
Blood
Diet
Abdominal Fat
Obesity
Diabetologie und Stoffwechsel
