CareLit Fachartikel

Analysis of the asthma susceptibility gene ORMDL3 using the model organism Drosophila melanogaster

K Kallsen, N Zehethofer, B Lindner, H Heine, T Roeder · Pneumologie · 2012 · Heft 05

Dokument
1110520
CareLit-ID
Jahr
2012
Publikation
PDF
nein
Metadaten
DOI
ja
zitierfähig

Bibliografische Angaben

Zeitschrift
Pneumologie
Autor:innen
K Kallsen, N Zehethofer, B Lindner, H Heine, T Roeder
Ausgabe
Heft 05 / 2012
Seiten
–
Erschienen: 2012-05-31 00:00:00
ISSN
0934-8387
DOI
10.1055/s-0032-1315467

Zusammenfassung

Asthma bronchiale is a chronic inflammatory disease of the lungs that is becoming a major health issue in many industrialized countries. Yet the molecular mechanisms that contribute to asthma pathogenesis are not well understood. Analysis of the relevance of asthma susceptibility genes may lead to a better understanding of the pathogenic mechanisms that cause this disease. In this study we analyzed the asthma susceptibility gene ORMDL3 using the model organism Drosophila melanogaster. ORMDL3 is an ER transmembrane protein whose functions have not been thoroughly elucidated. Thus, this study aimed to determine th…

Schlagworte

Asthma Ceramides Ceramide Lead Asthma bronchiale Pneumologie