CareLit Fachartikel
Artemin alters the functional properties of jugular C-fibers
A Weske, S Wiegand, R Nandigama, W Kummer, C Nassenstein · Pneumologie · 2012 · Heft 05
Dokument
1110521
CareLit-ID
Jahr
2012
Publikation
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Zusammenfassung
Neurotrophic factors have been shown to alter the functional properties of sensory C-fibers in allergic asthma. Artemin is a neurotrophic factor in the Glial Cell Line-Derived Neurotrophic Factor (GDNF) family of ligands, binds to its receptor GFRα3 and initiates intracellular signaling via co-receptor RET. Previously, we were able to demonstrate that a subpopulation of bronchopulmonary vagal C-fibers, namely the jugular cells, co-express GFRα3 and RET (Nassenstein et al., J Physiol 2010). These cells also showed expression of the transient receptor potential channel vanilloid 1 and ankyrin 1 (TRPV1 and TRPA1).…
Schlagworte
Neural Crest
Capsaicin
Calcium
Asthma
After
Pneumologie
