CareLit Fachartikel
Novel anti-inflammatory effects of alpha-1-antitrypsin on lung microvascular endothelial cells
S Wrenger, N Aggarwal, E Frenzel, T Welte, S Janciauskiene · Pneumologie · 2012 · Heft 05
Dokument
1110523
CareLit-ID
Jahr
2012
Publikation
PDF
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Metadaten
DOI
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Zusammenfassung
The acute phase protein alpha-1-antitrypsin (AAT) is released into the circulation at high concentrations (1.3–2mg/ml). The knowledge that an inherited AAT-deficiency increases susceptibility to chronic inflammatory conditions and that AAT is one of the major inhibitors of neutrophil proteases, suggests an important role for AAT in controlling acute phase inflammation and preventing development of chronic inflammation and tissue damage. Recent studies have also shown that exogenous AAT can be internalized by endothelial cells and suppresses cell apoptosis by inhibiting caspases-1 and 3. To further investigate th…
Schlagworte
Calpain
Alpha-1-Antitrypsin
alpha 1-Antitrypsin
Apoptosis
Caspases
Cytokine
Calcium
After
Pneumologie
