A new experimental model for chronic lung allograft damage
S Atanasova, A Evers, G Fuchs, K Petri, M Obert, A Fischer-Heuschkel, L Rabin, M Hirschburger, W Padberg, V Grau · Pneumologie · 2012 · Heft 05
Bibliografische Angaben
Zusammenfassung
Background: The long term survival of human lung allograft recipients is limited by the development of a fatal Bronchiolitis obliterans syndrome (BOS). Both, chronic allograft rejection and alloantigen independent factors like infections seem to contribute to the pathogenesis of BOS, which is still poorly understood. Relevant experimental models involving orthotopic pulmonary transplantation consistently resulting in chronic damage resembling BOS are still missing. The aim of our study is to establish and characterize an experimental model for BOS in the rat, which involves aspects of the most important clinical…
