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Functions of p38 mitogen-activated protein kinase alpha and beta in human pancreatic cancer cells

X Xie, X Tian, A Wieland, S Zhou, M Bachem, D Henne-Bruns, M Kornmann · Zeitschrift für Gastroenterologie · 2012 · Heft 06

Dokument
1110540
CareLit-ID
Jahr
2012
Publikation
PDF
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Metadaten
DOI
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Bibliografische Angaben

Zeitschrift
Zeitschrift für Gastroenterologie
Autor:innen
X Xie, X Tian, A Wieland, S Zhou, M Bachem, D Henne-Bruns, M Kornmann
Ausgabe
Heft 06 / 2012
Seiten
–
Erschienen: 2012-06-06 00:00:00
ISSN
0044-2771
DOI
10.1055/s-0032-1315827

Zusammenfassung

The p38 family of mitogen-activated protein kinases (p38 MAPKs) includes p38α (MAPK14), p38β (MAPK11), p38γ (MAPK12) and p38δ (MAPK13). Among these four isoforms, p38α and p38β are widely expressed and are involved in regulating cell proliferation, cell differentiation and cell apoptosis. Nothing is presently known about the role of the p38 MAPKs in human pancreatic cancers. In this study, we characterized for the first time the effects of p38α and p38β on human pancreatic cancer cells. Expression of p38α and p38β were determined by immunoblot in 7 cultured human pancreatic cancer cell lines. ShRNA inhibition of…

Schlagworte

General Surgery Apoptosis Movement China Tumor Zeitschrift für Gastroenterologie