Parvovirus H-1 (H-1PV) exerts oncolytic effects in cell culture models of human brain tumor-initiating cells
J Lacroix, R Josupeit, S Kern, C Herold-Mende, F Schlund, H Witt, T Milde, B Leuchs, SM Pfister, O Witt, JR Schlehofer, J Rommelaere · Klinische Pädiatrie · 2012 · Heft 11
Bibliografische Angaben
Zusammenfassung
Background: Oncolytic virotherapy with H-1PV represents a new therapeutic option for malignant brain tumors currently under clinical investigation in a phase I/IIa H-1PV trial on primary progressive or recurrent glioblastoma. Brain tumor-initiating cells such as glioblastoma „stem-like” cells or medulloblastoma-initiating cells are known to be relatively resistant to conventional anti-neoplastic agents and are thought to give rise to clinical tumor recurrence after standard treatment. This prompted us to address the question whether H-1PV is able to eliminate brain tumor-initiating cells in vitro. Methods and Re…
