Protective effects of FXR on hepatic lipid accumulation are mediated by hepatic FXR and independent of intestinal FGF15 signal
J Schmitt, B Kong, B Stieger, O Tschopp, SM Schultze, JC Mertens, P Frei, A Weber, B Müllhaupt, GL Guo, A Geier · Zeitschrift für Gastroenterologie · 2012 · Heft 09
Bibliografische Angaben
Zusammenfassung
Background: NALFD represents a chronic liver disease and cofactor in other metabolic diseases with worldwide growing incidence. There is growing evidence confirming a functional interaction between FXR-pathways and hepatic triglyceride metabolism. Methods: Liver- and intestine- specific Fxr knockout mice were under 1% cholesterol diet for 28 days or under a high fat diet. Histological examination of frozen tissue sections included Sudan III/H&E and BODIPY staining. Liver triglycerides, serum cholesterol and serum bile acids were measured. mRNA expression of several genes involved in bile acid homeostasis (Fxr, S…
